#22.1 DISCLOSURE FORM PDF PDF#
#22.1 DISCLOSURE FORM PDF TRIAL#
#22.1 DISCLOSURE FORM PDF FREE#

The global prevalence of dementia is expected to triple in the coming decades. Extended follow-up for dementia occurrence is important to inform on the potential long-term effects of multidomain interventions. Our results suggest that these interventions may be more effective in those with lower baseline cognitive functioning. We found no conclusive evidence that multidomain interventions reduce the risk of global cognitive decline, symptoms of depression or apathy in a mixed older population. The MMSE declined less in the intervention groups in those with MMSE <26 at baseline (N=250 MD: 0.84 95%CI: 0.15 to 1.54 p<0.001). No differences between intervention and control groups were observed on change in cognitive functioning scores and symptoms of depression and apathy scores in the pooled study population. We included 4162 individuals (median age 74 years, IQR 72, 76) with a median follow-up duration of 3.7 years (IQR 3.0 to 4.1 years). Prespecified subgroup analyses were performed for sex, educational level, baseline MMSE <26, history of hypertension, and history of stroke, myocardial infarction and/or diabetes mellitus. We analyzed crude scores with linear mixed models for overall cognitive function (Mini Mental State Examination ), and symptoms of depression and apathy (15-item Geriatric Depression Scale). MeasurementsДata on cognitive functioning, depressive symptoms and apathy were collected at baseline, 2 years and 3вЂ“4 years of follow-up as available per study. Multidomain interventions focused on cardiovascular and lifestyle related risk factors.

#22.1 DISCLOSURE FORM PDF FREE#

ParticipantsД¬ommunity-dwelling individuals, free from dementia at baseline.

#22.1 DISCLOSURE FORM PDF TRIAL#

Prevention of Dementia by Intensive Vascular Care trial (preDIVA) and Multidomain Alzheimer Preventive Trial (MAPT). Pooled analysis of individual participant data. We pooled individual participant data from two multi-domain intervention trials on cognitive function and symptoms of depression to increase power and facilitate subgroup analyses. When you provide inaccurate details with your fiscal reports, it may result in significant charges and create problems with your annual tax return.Cardiovascular risk factors and lifestyle factors are associated with an increased risk of cognitive decline and dementia in observational studies, and have been targeted by multidomain interventions.

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#22.1 DISCLOSURE FORM PDF PDF#

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